Применение «Биоженьшеня» в медицине и фармацевтике

Женьшень – реликтовое растение с узким ареалом распространения, с древних времен широко используется в восточной медицине, а с середины 20 столетия и в других странах мира.

Потребность в препаратах женьшеня растет. Ежегодно только через Гонконг – главный пункт распространения женьшеня, транспортируется свыше 5 тыс. т корней.

Препараты женьшеня являются адаптогенами, обладают психостимулирующим действием, регулируют обмен веществ, используются как общеукрепляющие и тонизирующие средства, способствуют оздоровлению и продлению жизни. Показаны иммуномодулирующее, кардиотропное, радиопротекторное, противоопухолевое, антиоксидантное, ранозаживляющее, антисклеротическое, противовоспалительное действия женьшеня.

Исследования биологической активности препаратов женьшеня продолжаются и открывают новые сферы их применения.

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Химический состав

Главными действующими веществами женьшеня являются тритерпеновые гликозиды – гингенозиды – тетрациклические тритерпены даммаранового ряда, а также гликозиды олеаноловой кислоты и ее производные. Помимо этого, в женьшене содержатся и другие вещества, обладающие биологической активностью – полиацетилены, β-ситостерин, полисахариды, эфирные масла, витамины, смолы, пектин, аминокислоты, микроэлементы.

Препараты женьшеня производят на основе водных и водно-спиртовых экстрактов или непосредственно из сухой массы корней и применяют в медицине в виде отваров, настоек, мазей, капсул и таблеток.

Женьшень также широко применяется в парфюмерно-косметической и пищевой промышленности.

Биоженьшень – клетки женьшеня, культивируемые in vitro на жидкой и агаризованной среде биотехнологическими методами. Биоженьшень сходен с нативным корнем по химическому составу и биологической активности и может быть использован как альтернатива природному источнику сырья.

разработка препарата в ОАО “Биохиммаш”

Применение биоженьшеня в медицине и фармацевтике

Биоженьшень обладает поливалентным адаптогенным эффектом; повышает устойчивость организма к экстремальным воздействиям: острой гипоксии, интенсивным физическим нагрузкам, гиподинамии, гипертонии, рентгеновскому облучению, действию бактериотоксинов, проявляет противоопухолевую активность.

На основе биоженьшеня в отечественной медицине изготовлена настойка (Tinctura Bioginseng). Настойка является официальным лекарственным средством, оказывает адаптогенное действие, применяется при умственном и физическом напряжении, переутомлении, гипотонии, неврастении, астенических состояниях.

К производству предложены таблетки биоженьшеня, которые обладают сорбционным, антиоксидантным и тонизирующим действием.

Разрабатывается новое перспективное лекарство для восстановления нарушений ЦНС и психических функций на основе гинзенозидов биоженьшеня.

Применение биоженьшеня в парфюмерно-косметической промышленности

Водно-спиртовой экстракт из биоженьшеня рекомендован как биологически-активная добавка для производства кремов для кожи, лосьонов, шампуней, пеномоющих средств. В отечественной промышленности было осуществлено производство крема «Лесная нимфа» с использованием биоженьшеня.

Применение биоженьшеня в пищевой промышленности

Экстракты биоженьшеня обладают уникальными свойствами и являются ценной пищевой добавкой. Разработаны рецептура и технология получения пищевых продуктов с добавкой биоженьшеня: «Сок и коктейль морковно-облепиховый и с биоженьшенем», кисломолочные продукты «Биотонус», йогурты, безалкогольные тонизирующие напитки. Выпущена опытная партия продуктов с добавкой биоженьшеня.

Возможности получения биоженьшеня на ОАО «Биохиммаш»

Выход биоженьшеня за цикл культивирования в аппаратах объемом 100 л составляет в среднем 600 г сухой биомассы клеток. В настоящее время имеется два аппарата емкостью 100 л и один аппарат 630 л, таким образом, за 2 недели (цикл культивирования) может быть наработано 3,7 кг сухой биомассы клеток женьшеня, которые содержат 5-7% ценных вторичных метаболитов (гинзенозидов) по сухому весу.

Стоимость 1 г сухой биомассы 1,5 долл. США.

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